TY - JOUR AU - Kondratiuk , Віталій AU - Petrova, Анна AU - Karpenko, Олена PY - 2021/07/30 Y2 - 2024/03/28 TI - QUALITY OF LIFE OF PATIENTS WITH CHRONIC KIDNEY DISEASE VD STAGES TREATED HEMODIALYSIS IN THE RELATIONSHIP WITH MELATONIN-FORMING DYSFUNCTION OF THE EPIPHYSIS JF - Actual Problems of Nephrology JA - APN VL - IS - 28 SE - Articles DO - 10.37321/nefrology.2021.28-04 UR - https://apn.org.ua/index.php/journal/article/view/32 SP - 37-45 AB - <p>Goal. To study the quality of life (QOL) in patients with end-stage chronic kidney disease (CKD) who are treated with hemodialysis (HD) and to determine its relationship with the melatonic function of the pineal gland.<br>Materials and methods. The study included 130 patients who are treated with the HD method (mean age 55 ± 13.7 years). QOL was assessed using the SF-36 questionnaire modified for patients with renal pathology. The concentration of melatonin in saliva was determined by the enzyme immunoassay using the Human MS (Melatonin Sulfate) ELISA Kit, Elabscience.<br>Results and discussion. QoL studies demonstrated its deterioration in 96% of the examined patients, to a greater extent due to the symptoms of “burdensome disease” and MPE disorders. Analysis of the total QOL indicator in patients with impaired MFE is 22.2% (p &lt;0.001) lower than the obtained indicator in the comparison group. The result of the scale «burden of disease» and SF-12 groups with pineal gland dysfunction by 57% (p &lt;0.001) and 44.5% (p &lt;0.001), respectively. The result of the «physical total component» of the group of the main group is 58.4% (p &lt;0.001) lower than the similar component of the comparison group. The sum of the scores of the patients in the main group for the «mental total component» is 32.3% (p &lt;0.001) less than the result of patients with preserved the melatonic function of the pineal gland.<br>Conclusions. The relationship between the deterioration of QOL and the violation of MFE was established. Patients with HD with impaired MFE are characterized by lower values: total QOL, severity of the disease, SF-12 total «physical components» and «mental components» than in patients with preserved MFE by 22.2%, 57%, 44.5%, respectively, 58.4% and 32.3% (all p &lt;0.001), which indicates the negative impact of disturbances in the circadian rhythms of melatonin on the quality of life of this severe cohort of patients.</p> ER -