KIDNEY BIOPSY – AN IMPORTANTTOOL FOR THE DIAGNOSIS, TREATMENT AND DETERMINATION OF THE PROGNOSIS OF PATIENTS WITH LUPUS NEPHRITIS

  • Violetta Dubovik Кафедра пропедевтики внутрішньої медицини №2 Національного медичного університету імені О.О. Богомольця, Київ
Keywords: lupus nephritis, renal biopsy, histology, molecular analysis, prognosis

Abstract

Introduction. Kidney damage can vary from mild to severe and occurs in 50% -70% of patients with systemic lupus erythematosus (SLE) [4], more often develops during 2-3 years [2]. Lupus nephritis (LN) has various morphological manifestations with different clinical signs and consequences. Percutaneous kidney biopsy is the gold standard for the diagnosis of LN according to the WHO classification since 1974 [1].

The purpose. This review reveals the importance of kidney biopsy for diagnosis and prognosis.

Material and methods. Review of contemporary and foreign literary sources; techniques – description, analysis, abstracting.

Results. There are many reports of clinical using of the renal biopsy classification of LN, but the number of studies evaluating its validity is not yet sufficient. Renal biopsy of LN provides vague data, which raises serious doubts about validity and clinical use, because it can lead to serious errors during diagnosis, treatment and prognosis.

Conclusions. The molecular analysis of the bioptate will be the key to a personalized approach to drug selection in LN. The molecular characteristics of kidney damage available with LN will provide the necessary supplements to more accurately classify the disease, predict outcomes, and further use of new therapeutics.

References

Компендіум. Системний червоний вовчак. – 22.08.2019. – https://compendium.com.ua/uk/tutorials-uk/vnutrishnya-meditsina/6-rozdil-revmatychni-khvoroby/6-6-sistemnij-chervonij-vovchak/
Корж А.Н., Іванов Д.Д. Ураження нирок при системних хворобах// Газета «Новости медицины и фа-рмации». – 2012. – N. 11 (421).
Стерлинг Дж.Уэст. Секреты ревматологии// М.: Геотар-Медиа. – 2018. – ст. 760.
Alrowaie F., AlTurki M., Alhusani A., Alqahtani A., Alhajlah M., Althubaiti A. Clinical features and outcome of lupus nephritis patients with crescent in renal biopsy// Nephrology Dialysis Transplantation. – 2017. – Vol. 32. – P. 503.
Alsuwaida A., Husain S., Alghonaim M., Al Oudah N. Strategy for second kidney biopsy in patients with lupus nephritis// Nephrology Dialysis Transplantation. – 2012. – Vol. 27. –
P. 1472-1478.
Bethunaickan R., Berthier C.C., Zhang W. Identification of stage specific genes associated with lupus nephritis and response to remission induction in NZB/W and NZM2410 mice// Arthritis Rheumatol. – 2014. – Vol. 66. – P. 2246-2258.
Girimaji N. Repeat renal biopsy as a predictor of outcome in patients with lupus nephritis// Nephrology Dialysis Transplantation. – 2019. – Vol. 34. - P. 236.
Golubeva Y., Salcedo R., Mueller C. Laser capture microdissection for protein and NanoString RNA analysis// Methods Mol Biol. – 2013. – Vol. 931. – P. 213-257.
Hill G.S., Delahousse M., Nochy D. Class IV-S versus class IV-G lupus nephritis: clinical and morphologic differences suggesting different pathogenesis// Kidney Int. – 2005. – Vol. 68. – P. 2288-2297.
Mittal B., Hurwitz S., Rennke H. New subcategories of class IV lupus nephritis: are there clinical, histologic, and outcome differences?// Am J Kidney Dis. – 2004. – Vol. 44. – P. 1050-1059.
Pakozdi A., Pyne D., Sheaff M., Rajakariar R. Utility of a repeat renal biopsy in lupus nephritis: a single centre experience// Nephrology Dialysis Transplantation. – 2018. – Vol. 33. – P. 507-513.
Parikh S.V., Ayoub I., Rovin B.H. The kidney biopsy in lupus nephritis: time to move beyond histology// Nephrology Dialysis Transplantation. – 2015. – Vol. 30. – P. 3-6.
Peterson K.S., Huang J.F., Zhu J. Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli// J Clin Invest. – 2004. – Vol. 113. – P. 1722-1733.
Restrepo-Escobar M., Granda-Carvajal P.A., Jaimes F. Systematic review of the literature on reproducibility of the interpretation of renal biopsy in lupus nephritis// Sage Journals. – 2017.
Satoskar A.A., Shapiro J.P., Bott C.N. Charac­terization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli// Mod Pathol. – 2012. – Vol. 25. –
P. 709-721.
Trendelenburg M., Lopez-Trascasa M., Potlu­kova E. High prevalence of anti-C1q antibodies in biop-sy-proven active lupus nephritis// Nephrology Dialysis Transplantation. – 2006. – Vol. 21. – P. 3115-3121.
Published
2020-03-19
How to Cite
Dubovik V. (2020). KIDNEY BIOPSY – AN IMPORTANTTOOL FOR THE DIAGNOSIS, TREATMENT AND DETERMINATION OF THE PROGNOSIS OF PATIENTS WITH LUPUS NEPHRITIS. Actual Problems of Nephrology, 25, 26-31. Retrieved from https://apn.org.ua/index.php/journal/article/view/5