CONTROL OF SECONDARY HYPERPARATIREOSIS BY INTRAVENOUS INTRODUCTION OF PARSABIV IN PATIENTS WITH CHRONIC KIDNEY DISEASE V D STAGE IN HEMODIALYSIS

Authors

  • Eduard Krasiuk Kyiv City Center of Nephrology and Dialysis, Candidate of Medical Sciences, Director
  • Eugenia Grigorieva KNP "Kyiv City Center of Nephrology and Dialysis" PhD, patron of the director
  • Y.P. Semeryk KNP "Kyiv City Center of Nephrology and Dialysis" MD

DOI:

https://doi.org/10.37321/nefrology.2021.29-05

Keywords:

chronic kidney disease, hemodialysis, etelcalcetide, parsabiv, cinacalcet, secondary hyperparathyroidism

Abstract

Introduction. Secondary hyperparathyroidism (VGPT), a common complication of chronic kidney disease characterized by elevated serum parathyroid hormone (PTH). Parsabiv (etecalcetide) is an intravenous calcimimetic that increases the sensitivity of the calciumsensitive receptor to calcium and reduces the secretion of PTH.
Goal. Evaluation of VGPT control by intravenous administration of Parsabiv in patients with end-stage chronic kidney disease (CKD) treated with hemodialysis (HD) compared with cinacalcet for oral administration.
Materials and methods. A prospective observational study included 40 patients with VGPT treated with HD who had not previously received appropriate treatment (ie, never received calcimimetics before), patients who had previously received cinacalcet, and patients who continued to receive cinacalcet. The primary endpoint for efficacy was the number of patients with a PTH reduction of more than 30% compared to baseline at the efficacy stage (weeks 12-14) and whether Parsabiv was more effective in controlling VGPT than cinacalcet. Secondary endpoints were presented by some patients who achieved a reduction in PTH levels of more than 50% from baseline and a reduction in PTH and calcium levels during the evaluation period.
Results and discussion. The study included data from 40 patients obtained during a 14-week follow-up period. The mean age of 40 patients was 47.62 ± 12.97 years, 70% were male. The average duration of dialysis was 8.3 ± 2.34 years. The mean PTH concentration before the start of the study and for 12-14 weeks was 1137.34 ± 544.84 and 838.7 ± 458.8 pg / ml and 1010.6± 478.53 and 760.8 ± 373.86 pg / Jr. in the Parsabiva and cinacalcet groups, respectively. The mean total calcium remained within the normal range in the Parsabiva group and in the cinacalcet group, although the decrease in total calcium was higher in the Parsabiva group (2.23% vs. 5.15%), in all cases it was not accompanied by symptoms.
Conclusions. The results of our observational study are of clinical interest. They confirm that the use of Parsabiva is a new important treatment option for patients with VGPT. Parsabiv has been shown to be more effective in controlling VGPT in patients compared with cinacalcet. In addition, the use of Parsabiv helps to reduce the stress caused by the need to take a large number of drugs, typical of dialysis patients, and thus may contribute to better adherence to the recommended treatment regimen and eliminate the risk of persistent VGPT. It is also important that Parsabiv does not interact with isoenzymes of the cytochrome P450 system, that is, there are no interactions with other drugs received by dialysis patients.
Further studies are needed to assess the clinical consequences, as well as efficacy and safety with long-term use.

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Published

2021-12-14

How to Cite

Krasiuk Е., Grigorieva Є., & Semeryk Ю. (2021). CONTROL OF SECONDARY HYPERPARATIREOSIS BY INTRAVENOUS INTRODUCTION OF PARSABIV IN PATIENTS WITH CHRONIC KIDNEY DISEASE V D STAGE IN HEMODIALYSIS. Actual Problems of Nephrology, (29), 51–57. https://doi.org/10.37321/nefrology.2021.29-05