CLINICAL AND PHARMACOLOGICAL FEATURES OF THE USE OF ALDOSTERONE ANTAGONISTS IN PATIENTS WITH HYPERTONIC DISEASE

Authors

  • Valentyna Moyseyenko Bogomolets National Medical University, MD, PhD, Professor
  • Vitaliy Bondur Bogomolets National Medical University
  • Artem Lyubitsky Bogomolets National Medical University 4th year student of the Medical Faculty №2

DOI:

https://doi.org/10.37321/nefrology.2021.29-04

Abstract

Introduction. Arterial hypertension is a widely spread disease with a tendency to year-over-year growth. It causes a number of comorbidities, has a great variety of manifestations and leads to life-threatening complications. In order to facilitate the situation, a lot of pharmacological remedies, were invented. Thus, a constantly aggravating disease needs further impovements in drug administration. Efficacy, economy and safety concerns are the most valuable aspects in terms of patient`s outcome, that`s why they have to be investigated and administered properly to reach the best possible effect.
Goal. Efficacy, specifics and safety concerns comparison of antihypertensive drugs spironolactone and eplerenone.
Materials and methods. Bibliographic – a theoretical analysis is carried out and a generalization of literature data is carried out, the actual content is analyzed. In the study, a questionnaire-survey method was used, as well as description, analysis, abstracting.
Results and discussion. Considering the diseases of urinary system, such as chronic kidney disease and hyperaldosteronism and cardiovascular system, of those, the arterial hypertension, both complicated and not, a greater therapeutic effect was reached in case of eplerenone administration. This drug satisfy the demands of clinicians not just in case of arterial hypertension, but also in case of albuminuria in II type diabetes, chronic kidney disease and hyperaldosteronism. And in terms of arterial hypertension, eplerenone was considered just as effective and more safe, comparing with spironolactone. Pharmacokinetics of eplerenone allow it to be much more specific to mineralocorticoid receptor blockade. With the whole picture realised, eplerenone has a great opportunities to compete with other drugs in treating states and diseases mentioned in this article.
Conclusion. Analyzing plenty of investigations, eplerenone can be recognized more safe and equally effective, comparing with spironolactone.

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Published

2021-12-14

How to Cite

Moyseyenko В., Bondur В., & Lyubitsky А. (2021). CLINICAL AND PHARMACOLOGICAL FEATURES OF THE USE OF ALDOSTERONE ANTAGONISTS IN PATIENTS WITH HYPERTONIC DISEASE. Actual Problems of Nephrology, (29), 42–50. https://doi.org/10.37321/nefrology.2021.29-04

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