VIOLATION OF MINERAL EXCHANGE IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND CARDIOVASCULAR DISEASES

  • Valentyna Moyseyenko Bogomolets National Medical University, MD, Professor
  • Taras Medvedyev Bogomolets National Medical University
Keywords: chronic kidney disease, heart, calcium, phosphorus, metabolism

Abstract

Introduction. It is known that patients with CKD are
more likely to die from cardiovascular causes than from
renal failure. These patients have almost 20 times higher
risk of cardiovascular events (CVD) [6]. In addition, even for
patients with CKD who do not require renal replacement
therapy, the rate of CVD is much higher than in patients
who reach end-stage renal disease and require renal
replacement therapy.
Goal. To study the parallels of mineral metabolism
disorders in patients with chronic kidney disease and
cardiovascular diseases.
Materials and methods. Review of modern and
foreign sources, analysis and discussion of a specific
clinical case; methods – description, analysis, abstracting.Results and discussion. Disorders of mineral
metabolism, in particular calcium-phosphorus homeostasis,
are presented and analyzed, are important complications
that occur in the early stages of chronic kidney disease
and progress with deteriorating renal function. A number
of studies in recent years have shown that higher or lower
than target levels of parathyroid hormone (PTH), Ca, P, Ca *
P product are closely correlated with increasing mortality of
nephrological patients [8, 9]. Thus, according to J. Floege
et al. (2011), in patients with stage V CKD and a PTH level
greater than 600 pg / ml, the risk of mortality is doubled
compared with patients in whom the PTH level is within the
target range [8]. In studies by Levin et al. it is shown that
the prevalence of secondary hyperparathyroidism (VGPT)
among patients with stage III – V CKD is 56% [10].
Conclusions. Patients on dialysis have disorders of
mineral metabolism, in particular calcium and phosphorus.
These disorders lead to excessive phosphate content.
Inhibition of these compensatory mechanisms requires
further study, as it plays an important role in the prevention
of cardiovascular complications in patients with chronic
kidney disease.

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Published
2020-12-22
How to Cite
Moyseyenko , V., & Medvedyev , T. (2020). VIOLATION OF MINERAL EXCHANGE IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND CARDIOVASCULAR DISEASES. Actual Problems of Nephrology, (26-27), 26-31. https://doi.org/10.37321/nefrology.2020.26-27-04