ГЕРПЕСВІРУСНІ ІНФЕКЦІЇ В НЕФРОЛОГІЇ

  • Dmytro Maltsev National Medical University named after О. Bogomolets, Institute of Experimental and Clinical Medicine, NMU named after О. Bogomolets
Keywords: herpes simplex viruses, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus, herpes viruses of 6, 7, 8 types, interstitial nephritis, glomerulonephritis, allogeneic kidney transplantation

Abstract

Herpes viruses are a group of opportunistic DNA-containing viral agents that have the property of pantropism, ie the ability to affect all organs and systems of the human body. The urinary system is no exception, so nephrologists should pay due attention to the problem of herpesvirus-associated lesions of the kidneys and other urinary organs.
This publication is a scientific review of the results of clinical trials and reports of clinical cases of herpesvirus infections in nephrological patients, published in recent years in peer-reviewed scientific periodicals cited in authoritative scientometric electronic databases PubMed and Embase.
The article considers data on direct herpesvirus kidney lesions by type of interstitial nephritis and glomerulonephritis. The need for differential diagnosis with similar lesions of the kidneys of autoimmune nature in such cases is emphasized. There are also data on indirect kidney damage caused by reactivated herpesviruses, including tropic to the renal parenchyma autoimmune, allergic and immunoinflammatory reactions, induction of tumor growth syndrome and the development of lymphoproliferative syndromes, as well as herpesvirus-associated metabolic disorders with nephrotoxic effects. Information on herpesvirus infections in allogeneic kidney recipients is presented separately. Problems of nephrotoxicity in the use of specific antiherpetic chemotherapeutics in patients with chronic renal failure are elucidated.
The article is designed to form a modern comprehensive understanding in nephrologists of the problem of herpesvirus infections in patients with kidney disease.

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Published
2020-12-22
How to Cite
Maltsev, D. (2020). ГЕРПЕСВІРУСНІ ІНФЕКЦІЇ В НЕФРОЛОГІЇ. Actual Problems of Nephrology, (26-27), 15-25. https://doi.org/10.37321/nefrology.2020.26-27-03