BIOCHEMICAL CRITERIA FOR ASSESSMENT OF KIDNEY FUNCTION IN PATIENTS WITH PLASMA CELL MYELOMA SUFFERED AFTER THE CHORNOBYL ACCIDENT
The aim of the work was to study the peculiarities of biochemical parameters of renal function in plasma cell myeloma patients suffered after the Chornobyl accident.
Materials and Methods. The peculiarities of the disease course in 64 patients with plasma cell myeloma (PCM), who were examined and treated in the Department of Radiation Oncohematology of State institution «Natinal Research Center for Radiation Medicine of NAMS of Ukraine» during 2010-2017 were analyzed. The main clinical and laboratory characteristics of PCM were evaluated (LDH, β2-microglobulin, albumin, serum calcium, urea, creatinine and hemoglobin level) in connection with radiation history (participants of the Chornobyl accident clean up activity, evacuees from the zones of resettlement, residents of contaminated territories and group comparison), the PCM stages according to the classifications of Durie-Salmon et al. (1975) and ISS (1985).
Results and conclusion. It was found that in PCM patients with a burdened radiation history, compared to non-irradiated patients, the level of β2-micro-globulin (p = 0.02) and calcium (p = 0.04) was significantly increased in. It was confirmed that the most informative characteristics in PCM patients are urea (F = 3.58; p = 0.05) and serum albumin (F = 4.00; p = 0.05). Significant correlation of the main parameters characterizing the renal function in PCM patients with the anemia and the level of calcium, which depends on the degree of osteolytic bone damage, was confirmed. Differences in clinical and hematological signs in PCM patients suffered after the Chornobyl accident and non-irradiated persons have been revealed and formed the basis for predicting the effectiveness of treatment that need further research in this area.
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